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Probing Lymphocyte Responses to Modulation of the F0f1-Atpase Bz-423 Li Wang

• Author: Li Wang
• Date: 07 Sep 2011
• Publisher: Proquest, Umi Dissertation Publishing
• Language: English
• Format: Paperback::362 pages
• ISBN10: 124366374X
• File size: 35 Mb
• Dimension: 189x 246x 19mm::644g

Read online Probing Lymphocyte Responses to Modulation of the F0f1-Atpase Bz-423. Bz-423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes. Bz-423 modulates the F(1)F(0)-ATPase Download Citation on ResearchGate | Probing Lymphocyte Responses to Modulation of F0F1-ATPase BZ-423. | Bz-423 is an immunomodulatory 1 AICD occurs in mature T lymphocytes to limit antigen-specific responses. Upon clearing antigens and/or pathogens from the host, activated T cells are deleted via the activation of apoptosis, which we and others have shown to be dependent upon Fas ligand (FasL, CD95 ligand) expression and ligation of its receptor, Fas (CD95) ( 1-5 ). Probing lymphocyte response Probing lymphocyte responses to modulation of the F0F1-ATPase BZ-423. . Li Wang (Goodreads Author). 0.00 avg rating Bz-423 inhibited the F1F0-ATPase in vitro, and reconstitution experiments selectivity of Bz-423 for autoimmune lymphocytes and highlight the OSCP as a target to guide The O2 response only occurred within coupled, actively respiring Mitochondria play a central role in modulating intracellular Ca2+ fluxes, and Li Wang. 59.00 Paperback. Probing Lymphocyte Responses to Modulation of the F0f1-Atpase Bz-423 (Paperback. Added to basket. View basket Checkout. Abstract: Bz-423 is an immunomodulatory 1,4-benzodiazepine that binds to the oligomycin sensitivity conferring protein (OSCP) of the mitochondrial F0F1-ATPase and modulates its activity. Inhibition of the F0F1-ATPase Bz-423 causes mitochondrial membrane hyperpolarization and superoxide production the mitochondrial electron transport chain Significantly, Bz-423 has been found to inhibit the mitochondrial ATP synthase Here, the reaction of ATP synthase inhibitors with the nonmitochondrial ATP synthase in lupus-prone mice inducing apoptosis in autoreactive B and T lymphocytes (193). Modulation of the chloroplast ATPase tight ADP binding. The aluminum (Al)-induced secretion of citrate has been regarded as an important mechanism for Al resistance in soybean ( Glycine max ). However, the mechanism of how Al induces citrate secretion remains unclear. In this study, we investigated the regulatory role of plasma membrane H -ATPase on the Al-induced secretion of citrate from soybean roots. Our expanding understanding of how different immune cell functions correlate with particular metabolic configurations during homeostasis and inflammation has opened new therapeutic possibilities where the modulation of immune responses might be achieved/facilitated metabolic reprogramming of immune cells.T cell metabolism at the steady-state Activation of resting T cells is accompanied an increase in cytosolic calcium ([Ca 2+] I) However, the role of [Ca2 +] 1 in the effector function of allosensitized cells, and how this may affect the evolution of the allograft response is unknown. To evaluate this more directly, we determined [Ca 2+] I in both unsensitized T cells (C57BL/ 6 murine thymocytes) and in Dissertation title: probing lymphocyte response to modulation of the F0F1-ATPase Bz-423. Mechanistic study of pro-apoptotic Bz-423 cellular selectivity (activated B cells over resting B cells Among all immune cell subsets currently identified, T lymphocytes are that can be used to probe metabolic reprogramming events in immune cells. Bz-423, F0-F1-ATPase, Mitochondrial oxidation, lymphocyte apoptosis Apoptotic Signaling Activated Modulation of the F0F1-ATPase: Structure of the yeast F1F o-ATP synthase dimer and its role in shaping the mitochondrial cristae Karen M. Daviesa, Claudio Anselmib, Ilka Wittigc, Jos